L-2-hydroxycarboxylate dehydrogenase (NAD+)

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L-2-hydroxycarboxylate dehydrogenase (NAD+) Identifiers EC number 1.1.1.337 CAS number 81210-65-3 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Search PMC articles PubMed articles NCBI proteins L-2-hydroxycarboxylate dehydrogenase (NAD+) (EC 1.1.1.337, (R)-sulfolactate:NAD+ oxidoreductase, L-sulfolactate dehydrogenase, (R)-sulfolactate dehydrogenase, L-2-hydroxyacid dehydrogenase (NAD+), ComC) is an enzyme with systematic name (2S)-2-hydroxycarboxylate:NAD+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction (2S)-2-hydroxycarboxylate + NAD+ ⇌ {\displaystyle \rightleftharpoons } 2-oxocarboxylate + NADH + H+ The enzyme from the archaeon Methanocaldococcus jannaschii uses as a substrate multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate. References[edit] ^ Graupner, M.; Xu, H.; White, R. H. (2000). "Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea". J. Bacteriol. 182: 3688–3692. doi:10.1128/JB.182.13.3688-3692.2000. PMC 94539. PMID 10850983.  ^ Graupner, M.; White, R. H. (2001). "The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea". Biochim. Biophys. Acta. 1548: 169–173. doi:10.1016/S0167-4838(01)00220-5. PMID 11451450.  ^ Graham, D. E.; White, R. H. (2002). "Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics". Nat. Prod. Rep. 19: 133–147. doi:10.1039/b103714p. PMID 12013276.  ^ Rein, U.; Gueta, R.; Denger, K.; Ruff, J.; Hollemeyer, K.; Cook, A. M. (2005). "Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA". Microbiology. 151 (Pt 3): 737–747. doi:10.1099/mic.0.27548-0. PMID 15758220.  External links[edit] L-2-hydroxycarboxylate dehydrogenase (NAD ) at the US National Library of Medicine Medical Subject Headings (MeSH) v t e Oxidoreductases: alcohol oxidoreductases (EC 1.1) 1.1.1: NAD/NADP acceptor 3-hydroxyacyl-CoA dehydrogenase 3-hydroxybutyryl-CoA dehydrogenase Alcohol dehydrogenase Aldo-keto reductase 1A1 1B1 1B10 1C1 1C3 1C 무료야동

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